Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 9/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.45 |
| ▸ | HTR3B | O95264 | 4/20 | 0.45 |
| ▸ | HTR3A | P46098 | 4/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548204 | 1.00 | ADRB1 (0.46) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8257694 | 0.88 | CYP3A4 (0.48) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL38664668 | 0.88 | CYP3A4 (0.48) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7961776 | 0.80 | OGA (0.47) | MMP2ADAMTS5OGACYP3A4CYP2C9 | |
| SCHEMBL27644544 | 0.79 | DYRK2 (0.46) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23075831 | 0.76 | MMP2 (0.45) | HTR3AMMP2ADAMTS5OGACYP3A4 | |
| Anisole SCHEMBL27515292 | 0.76 | ADRB1 (0.54) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL21091414 | 0.75 | GAA (0.57) | OGATP53CYP3A4HTR1ACYP2C9 | |
| SCHEMBL5798538 | 0.75 | PDE3B (0.46) | MMP2ADAMTS5OGATP53CYP3A4 | |
| SCHEMBL11358375 | 0.73 | MEN1 (0.65) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718588-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718588-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | ADAMTS1, ADAMTS5, ADAMTS7 | ADRB1 3478/4885HTR3E 1217/4885HTR3B 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.