Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 9/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.87 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.87 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.56 |
| ▸ | HTR3B | O95264 | 2/20 | 0.56 |
| ▸ | HTR3A | P46098 | 2/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061895 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 | |
| SCHEMBL3678685 | 0.93 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 | |
| SCHEMBL5656979 | 0.89 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA1CHRNA7CHRNB4 | |
| Fumaric Acid SCHEMBL27545124 | 0.88 | CHRNB2 (0.77) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 | |
| SCHEMBL12205345 | 0.86 | CHRNB2 (0.75) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB2 | |
| SCHEMBL23458773 | 0.81 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 | |
| SCHEMBL22236832 | 0.80 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 | |
| SCHEMBL6094605 | 0.79 | CHRNB2 (0.78) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| Fumaric Acid SCHEMBL27562175 | 0.79 | CHRNB2 (0.78) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL254693 | 0.78 | ADRB1 (1.00) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718588-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718588-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | ADAMTS1, ADAMTS5, ADAMTS7 | CHRNB2 4643/4885CHRNA4 4788/4885CHRNA1 3701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.