Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30613768 | 0.79 | MAPK1 (0.45) | HTR2CMAPK1STAT3DPP4DPP7 | |
| SCHEMBL27042492 | 0.74 | MAPK1 (0.42) | TEAD1MAPK1STAT3DPP4DPP7 | |
| SCHEMBL25343345 | 0.71 | TDP2 (0.36) | NAAAHRH4TEAD1TEAD4TEAD2 | |
| Hydrochloric Acid SCHEMBL30613776 | 0.70 | HTR2C (0.67) | HTR2CS1PR1TNKS2 | |
| SCHEMBL21097251 | 0.69 | TNKS2 (0.68) | HRH4HTR2CS1PR1KIF11TNKS2 | |
| SCHEMBL11186819 | 0.67 | TRPV1 (0.46) | HRH4CYP11B2TNKS2TRPV3 | |
| SCHEMBL11190992 | 0.64 | MAPT (0.39) | CYP11B2TNKS2TRPV3 | |
| SCHEMBL11192162 | 0.63 | TRPV3 (0.37) | CYP11B2TRPV3 | |
| SCHEMBL30613785 | 0.62 | HTR2C (0.51) | HTR2CMAPK1TNKS2 | |
| SCHEMBL11179410 | 0.61 | DRD2 (0.36) | CYP11B2TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472636-A2 | TETRAHYDROPYRIDOPYRIMIDINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023150619-A2 | TETRAHYDROPYRIDOPYRIMIDINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-08-10 | — | — | WO | disclosed |