Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CCL2 | P13500 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138594 | 0.83 | HCRTR2 (0.36) | HSD11B1HCRTR1HCRTR2SMYD3ROCK2 | |
| SCHEMBL29138621 | 0.82 | GPR119 (0.44) | HSD11B1 | |
| SCHEMBL30639338 | 0.82 | GPR119 (0.44) | HSD11B1 | |
| SCHEMBL3950691 | 0.77 | DRD2 (0.44) | HSD11B1 | |
| SCHEMBL2636853 | 0.74 | HSD11B1 (0.60) | HSD11B1AOC3 | |
| SCHEMBL27195383 | 0.71 | CCNE1 (0.34) | SMYD3ROCK2PRKG1 | |
| SCHEMBL25189423 | 0.70 | TRPC6 (0.43) | — | |
| SCHEMBL17667436 | 0.70 | ROCK2 (0.44) | HSD11B1ROCK2PRKG1 | |
| SCHEMBL15646781 | 0.69 | HSD11B1 (0.38) | HSD11B1HCRTR2SMOSMYD3CHRM2 | |
| SCHEMBL1740550 | 0.69 | HSD11B1 (0.48) | HSD11B1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117247395-A | PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |