Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 16/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067561 | 1.00 | AADAT (0.46) | AADATBACE1ALDH1A1P2RX7TRPA1 | |
| SCHEMBL3071622 | 0.83 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL3816465 | 0.79 | MAPK14 (0.43) | ALDH1A1 | |
| SCHEMBL3058446 | 0.78 | ALDH1A1 (0.47) | AADATBACE1ALDH1A1P2RX7 | |
| SCHEMBL3816468 | 0.74 | RAB9A (0.36) | ALDH1A1 | |
| SCHEMBL3058822 | 0.73 | AADAT (0.54) | AADATBACE1ALDH1A1 | |
| SCHEMBL8168420 | 0.70 | HCRTR1 (0.39) | ALDH1A1 | |
| SCHEMBL3060078 | 0.70 | GRM1 (0.35) | ALDH1A1 | |
| SCHEMBL3053874 | 0.70 | ALDH1A1 (0.52) | BACE1ALDH1A1 | |
| SCHEMBL19815197 | 0.69 | BACE1 (0.50) | BACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267697-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2010-10-21 | — | — | US | claimed |
| EP-2099754-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-16 | — | — | EP | claimed |
| WO-2008073929-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| US-20100267697-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267697-A1 | ION CHANNEL MODULATORS | CACNA1E, CACNA1A, CACNA1S | AADAT 3680/4885BACE1 1907/4885ALDH1A1 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.