Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11418045 | 0.75 | DRD2 (0.38) | GRIN1GRIN2BDRD2DRD3LMNA | |
| SCHEMBL30667082 | 0.75 | DRD2 (0.38) | GRIN1GRIN2BDRD2DRD3LMNA | |
| SCHEMBL24677864 | 0.70 | DRD2 (0.37) | GRIN1GRIN2BDRD2DRD3LMNA | |
| SCHEMBL20840517 | 0.70 | DRD2 (0.36) | GRIN1GRIN2BDRD2DRD3AVPR1A | |
| SCHEMBL19908368 | 0.70 | GRIN1 (0.40) | GRIN1GRIN2BDRD2DRD3 | |
| SCHEMBL30341540 | 0.70 | DRD2 (0.36) | GRIN1GRIN2BDRD2DRD3AVPR1A | |
| SCHEMBL31684529 | 0.69 | AKT1 (0.34) | GRIN1GRIN2B | |
| SCHEMBL10683653 | 0.69 | SIGMAR1 (0.39) | MAOAMAOBBACE1 | |
| SCHEMBL2374703 | 0.68 | MAOA (0.54) | MAOAMAOBGAA | |
| SCHEMBL11474711 | 0.66 | MEN1 (0.47) | MAOAMAOBLMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543437-A1 | 3-?HSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250480-A1 | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2023-12-28 | — | — | WO | disclosed |