Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.54 |
| ▸ | SGK1 | O00141 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.45 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29114612 | 1.00 | ALPL (0.54) | ALPLSGK1MAPK1PTK2BALDH1A1 | |
| SCHEMBL28565925 | 0.87 | SGK1 (0.49) | SGK1PTK2BMAPTHTT | |
| SCHEMBL27561521 | 0.80 | ALPL (0.69) | ALPLSGK1MAPK1PTK2BALDH1A1 | |
| SCHEMBL17101699 | 0.80 | LMNA (0.47) | MAPK1ALDH1A1MAPT | |
| SCHEMBL29894281 | 0.77 | LMNA (0.53) | MAPK1PTK2BALDH1A1MAPTHTT | |
| SCHEMBL28687026 | 0.77 | LMNA (0.53) | MAPK1PTK2BALDH1A1MAPTHTT | |
| SCHEMBL28675493 | 0.76 | PTK2B (0.51) | PTK2BMAPT | |
| SCHEMBL23846522 | 0.75 | POLB (0.60) | ALPLSGK1PTK2BMAPTIDH1 | |
| SCHEMBL29114611 | 0.74 | CCR2 (0.50) | ALDH1A1MAPTHTTHSP90AA1HSP90AB1 | |
| SCHEMBL30646283 | 0.74 | CCR2 (0.50) | ALDH1A1MAPTHTTHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062817-A | Pyrazolo [3,4-D ] pyrimidin-6-yl-sulfonamide derivatives for SGK-1 inhibition | 斯瑞福治疗股份有限公司 | 2023-11-14 | — | — | CN | disclosed |