Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101827 | 0.88 | NR3C2 (0.54) | LMNAMAPTTP53NR3C1PGR | |
| SCHEMBL17101688 | 0.86 | LMNA (0.51) | LMNAMAPTTP53NR3C1NR3C2 | |
| SCHEMBL17101682 | 0.82 | LMNA (0.51) | LMNAMEN1KMT2ANR3C2GAA | |
| SCHEMBL17101795 | 0.80 | CXCR4 (0.58) | LMNANR3C1KMT2ANR3C2ALDH1A1 | |
| SCHEMBL30646271 | 0.80 | ALPL (0.54) | MAPTALDH1A1MAPK1 | |
| SCHEMBL29114612 | 0.80 | ALPL (0.54) | MAPTALDH1A1MAPK1 | |
| SCHEMBL17101704 | 0.79 | ALDH1A1 (0.61) | LMNATP53MEN1KMT2AALDH1A1 | |
| SCHEMBL17101822 | 0.78 | HSD11B1 (0.61) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL17101797 | 0.78 | CXCR4 (0.52) | MAPTTP53KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL17101702 | 0.78 | HTT (0.46) | LMNAMAPTTP53KMT2ANR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |