Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23661 | 0.80 | TSHR (0.75) | GAATSHRMAPK1RAB9AMEN1 | |
| SCHEMBL23072 | 0.77 | CYP3A4 (0.45) | GAATSHRMAPK1RAB9AMEN1 | |
| SCHEMBL31160 | 0.77 | GAA (0.62) | GAATSHRMAPK1RAB9AMEN1 | |
| SCHEMBL4823200 | 0.77 | DRD2 (0.40) | GAATSHRKMT2ACYP1A2CYP2C19 | |
| SCHEMBL30666 | 0.76 | HSD17B1 (0.59) | GAARAB9AMEN1KMT2AMAPT | |
| SCHEMBL20694277 | 0.74 | GAA (0.47) | GAATSHRMAPK1RAB9AKMT2A | |
| SCHEMBL13640332 | 0.73 | CA12 (0.59) | GAAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL45838 | 0.72 | CASR (0.47) | GAATSHRRAB9AMEN1KMT2A | |
| SCHEMBL4821120 | 0.72 | ACHE (0.40) | GAATSHRKMT2ACYP1A2CYP2C19 | |
| SCHEMBL31285 | 0.72 | HSD17B1 (0.51) | GAATSHRRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |