Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18186481 | 0.87 | HSD17B10 (0.42) | HSD17B10TDP1LMNAMAPK1HTT | |
| SCHEMBL27540803 | 0.85 | HSD17B10 (0.50) | HSD17B10TDP1LMNAMAPK1HTT | |
| SCHEMBL18393916 | 0.84 | KDM4E (0.44) | HSD17B10TDP1LMNARAB9AMAPT | |
| SCHEMBL28424948 | 0.83 | HSD17B10 (0.44) | HSD17B10TDP1LMNAMAPK1HTT | |
| SCHEMBL27731624 | 0.82 | HSD17B10 (0.52) | HSD17B10TDP1MAPTMEN1KMT2A | |
| SCHEMBL15573104 | 0.81 | HSD17B10 (0.46) | HSD17B10TDP1MAPTMEN1KMT2A | |
| SCHEMBL31012417 | 0.81 | HSD17B10 (0.46) | HSD17B10TDP1MAPTMEN1KMT2A | |
| SCHEMBL670626 | 0.79 | TPMT (0.49) | HSD17B10TDP1HTTMAPTMEN1 | |
| SCHEMBL6422815 | 0.79 | HSD17B10 (0.44) | HSD17B10TDP1LMNAMAPK1HTT | |
| SCHEMBL4903560 | 0.79 | PKM (0.58) | HSD17B10TDP1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320222-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED LTD (CN) | 2025-10-16 | — | — | US | disclosed |
| EP-4532500-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED Limited (CN) | 2025-04-09 | — | — | EP | disclosed |
| CN-119301129-A | Tricyclic compounds and uses thereof | 和记黄埔医药（上海）有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023232025-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED LIMITED (CN) | 2023-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250320222-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | CYP11B2, CYP11B1, CYP3A7 | HSD17B10 201/4885TDP1 979/4885LMNA 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.