SCHEMBL30676989

SCHEMBL30676989

COc1ccc(C(=O)c2cc(Br)c3cc(C(F)(F)F)ccn23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ RXFP1 Q9HBX9 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ MAOB P27338 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ BCHE P06276 1/20 0.41
▸ ACHE P22303 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.40
▸ GAA P10253 2/20 0.40
▸ CYP1A1 P04798 1/20 0.39
▸ CYP1B1 Q16678 1/20 0.39
▸ TUBB4A P04350 1/20 0.39
▸ TUBB P07437 1/20 0.39
▸ TUBA3C P0DPH7 1/20 0.39
▸ TUBA1B P68363 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29547648 0.88 SRD5A2 (0.43) MAPTMEN1RAB9AKMT2ANPSR1
SCHEMBL26300717 0.86 PTGDR2 (0.46) MAPTMAPK1MAOBKDM4EBCHE
SCHEMBL26300627 0.84 PTGDR2 (0.47) MAPTMAPK1MAOBKDM4EBCHE
SCHEMBL26300425 0.84 PTGDR2 (0.47) MAPTMAPK1MAOBKDM4EBCHE
SCHEMBL25400667 0.84 FNTA (0.47) MAPTLMNAHPGD
SCHEMBL26300691 0.83 ALDH1A1 (0.46) RXFP1MAOBALDH1A1GAATUBB4A
SCHEMBL26300657 0.82 PTGDR2 (0.43) MAPTMAOBKDM4EBCHEACHE
SCHEMBL25402588 0.82 LMNA (0.46) MAPTMAPK1RXFP1MEN1LMNA
SCHEMBL29547156 0.81 L3MBTL1 (0.36) MAPTMAPK1RXFP1MEN1LMNA
SCHEMBL26300580 0.81 PTGDR2 (0.46) MAOBALDH1A1TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4233864-B1 COMPOSITION COMPRISING AN INDOLIZINE DERIVATIVE AND A CYCLIC DINUCLEOTIDE AS ACTIVE AGENTS UNIV AJOU IND ACADEMIC COOP FOUND (KR) 2025-02-12 — — EP disclosed
US-20230390319-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2023-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230390319-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT STING1, IRF3, IFNG MAPT 4769/4885MAPK1 1471/4885RXFP1 1505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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