Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 17/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590413 | 1.00 | HTR2A (0.44) | HTR2AHTR2BMRGPRX1HTR2CGABRA1 | |
| SCHEMBL21590700 | 0.92 | GABRA1 (0.46) | GABRA1 | |
| SCHEMBL30694848 | 0.92 | GABRA1 (0.46) | GABRA1 | |
| SCHEMBL23169040 | 0.91 | GABRA1 (0.44) | GABRA1 | |
| SCHEMBL21590646 | 0.90 | L3MBTL1 (0.47) | GABRA1 | |
| SCHEMBL23169059 | 0.90 | GABRA1 (0.47) | GABRA1 | |
| SCHEMBL21590479 | 0.89 | GABRA1 (0.40) | GABRA1 | |
| SCHEMBL23150864 | 0.89 | GABRA1 (0.40) | GABRA1 | |
| SCHEMBL21590636 | 0.89 | GABRA1 (0.40) | GABRA1 | |
| SCHEMBL21590682 | 0.88 | GABRA1 (0.44) | GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-12-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840528-B2 | Isoxazolyl ether derivatives as GABAA α5 PAM | GABRA5, GABRA2, GABRB2 | HTR2A 479/4885HTR2B 332/4885MRGPRX1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.