Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 15/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699937 | 1.00 | CCNK (0.44) | CCNKCDK12HCRTR1SYKCCR2 | |
| SCHEMBL30699932 | 0.83 | LMNA (0.34) | CCNKCDK12KDM4EABL1LMNA | |
| SCHEMBL30700450 | 0.82 | GPR119 (0.38) | HCRTR1KDM4EABL1LMNA | |
| SCHEMBL30700477 | 0.81 | CCNK (0.41) | CCNKCDK12HCRTR1 | |
| SCHEMBL30700376 | 0.79 | ABHD6 (0.39) | HCRTR1KDM4EABL1LMNAGAA | |
| SCHEMBL30700504 | 0.78 | MGLL (0.40) | CCNKCDK12KDM4EABL1LMNA | |
| SCHEMBL30700306 | 0.78 | LMNA (0.36) | KCNH2KDM4EABL1LMNAGAA | |
| SCHEMBL25146253 | 0.77 | HCRTR1 (0.39) | CCNKCDK12HCRTR1 | |
| SCHEMBL30408525 | 0.77 | HCRTR1 (0.39) | CCNKCDK12HCRTR1 | |
| SCHEMBL25324903 | 0.77 | CCNK (0.38) | CCNKCDK12HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |