Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 6/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700264 | 0.86 | MGLL (0.43) | TRPC6HSD11B1MGLLALDH1A1 | |
| SCHEMBL30700286 | 0.80 | MGLL (0.41) | KDM5AHSD11B1MGLL | |
| SCHEMBL25253203 | 0.73 | SLC6A9 (0.40) | KDM5ATRPC6ALDH1A1SLC6A9USP30 | |
| SCHEMBL30700936 | 0.73 | MGLL (0.39) | HSD11B1MGLL | |
| SCHEMBL30700701 | 0.72 | RAB9A (0.35) | KDM5AHSD11B1ALDH1A1USP30 | |
| SCHEMBL30700917 | 0.72 | MGLL (0.36) | KDM5AHSD11B1MGLL | |
| SCHEMBL30700024 | 0.71 | CA12 (0.39) | HSD11B1MGLLALDH1A1USP30 | |
| SCHEMBL27291239 | 0.71 | MGLL (0.41) | KDM5AMGLL | |
| SCHEMBL30700767 | 0.71 | MGLL (0.38) | HSD11B1MGLL | |
| SCHEMBL30700456 | 0.71 | APLNR (0.39) | HSD11B1MGLLALDH1A1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |