Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 5/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27195380 | 0.91 | HCAR2 (0.36) | ALDH1A1MAPTKDM5ABACE1HCAR2 | |
| SCHEMBL30700478 | 0.75 | HSD11B1 (0.38) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30700024 | 0.75 | CA12 (0.39) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30700264 | 0.74 | MGLL (0.43) | TP53ALDH1A1HSD11B1 | |
| SCHEMBL27195383 | 0.74 | CCNE1 (0.34) | — | |
| SCHEMBL30700456 | 0.74 | APLNR (0.39) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30700136 | 0.74 | PDE4B (0.34) | — | |
| SCHEMBL31308011 | 0.74 | PDE4B (0.34) | — | |
| SCHEMBL27291239 | 0.74 | MGLL (0.41) | RAB9ANPC1MAPTATMKDM5A | |
| SCHEMBL21460157 | 0.74 | HCAR2 (0.43) | USP30KDM5AHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |