SCHEMBL307046

SCHEMBL307046

CCc1cccc([SiH3])c1[SiH3]

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.48
GABRB2 P47870 4/20 0.48
MAPT P10636 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HTR1A P08908 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
MGLL Q99685 1/20 0.34
PDK2 Q15119 1/20 0.34
KCNH2 Q12809 2/20 0.33
SCN5A Q14524 2/20 0.33
NLRP3 Q96P20 1/20 0.33
ANPEP P15144 1/20 0.33
DPP4 P27487 1/20 0.33
DAO P14920 1/20 0.32
CACNA1C Q13936 1/20 0.32
ELANE P08246 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28256638 0.87 GABRA1 (0.55) GABRA1GABRB2MAPTNPSR1L3MBTL1
SCHEMBL88662 0.81
Hydrochloric Acid SCHEMBL27502087 0.79 GABRA1 (0.46) GABRA1GABRB2MAPTNPSR1L3MBTL1
Fluoride SCHEMBL27930947 0.79 GABRA1 (0.46) GABRA1GABRB2MAPTNPSR1L3MBTL1
SCHEMBL1049593 0.78 GABRA1 (0.46) GABRA1GABRB2MAPTNPSR1L3MBTL1
SCHEMBL8521469 0.73 GABRA1 (0.46) GABRA1GABRB2MAPTNPSR1L3MBTL1
SCHEMBL18091842 0.72 CLCN2 (0.53) GABRA1GABRB2
SCHEMBL7945247 0.72 GABRA1 (0.40) GABRA1GABRB2L3MBTL1PDK2
SCHEMBL9811046 0.71 PTGS2 (0.40) GABRA1GABRB2MAPTNPSR1L3MBTL1
SCHEMBL4306695 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919836-B1 HYDROPHOBIC COATING COMPRISING A PRIMING INCLUDING A BIS-SILANE AND A HYDROPHOBIC LAYER INCLUDING A FLUORINATED ALKYSILANE SAINT GOBAIN (FR) 2017-05-10 EP disclosed
US-8092913-B2 Hydrophobic coating comprising a priming including a bis-silane and a hydrophobic layer including a fluorinated alkysilane SAINT-GOBAIN GLASS FRANCE (FR) 2012-01-10 US disclosed
US-20090214809-A1 HYDROPHOBIC COATING COMPRISING A PRIMING INCLUDING A BIS-SILANE AND A HYDROPHOBIC LAYER INCLUDING A FLUORINATED ALKYSILANE SAINT-GOBAIN GLASS FRANCE (FR) 2009-08-27 US disclosed
EP-1919836-A2 HYDROPHOBIC COATING COMPRISING A PRIMING INCLUDING A BIS-SILANE AND A HYDROPHOBIC LAYER INCLUDING A FLUORINATED ALKYSILANE SAINT-GOBAIN GLASS FRANCE (FR) 2008-05-14 EP disclosed
WO-2007012779-A2 HYDROPHOBIC COATING COMPRISING A PRIMING INCLUDING A BIS-SILANE AND A HYDROPHOBIC LAYER INCLUDING A FLUORINATED ALKYSILANE SAINT-GOBAIN GLASS FRANCE (FR) 2007-02-01 WO disclosed