Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30710250 | 1.00 | LMNA (0.42) | LMNATP53HDAC1HDAC6HSP90AA1 | |
| SCHEMBL30710394 | 0.90 | CHRM3 (0.41) | HDAC1HDAC6NR1H2UCHL1USP30 | |
| SCHEMBL30710477 | 0.84 | MEN1 (0.41) | NR1H2UCHL1GHSRTRPV1ESR2 | |
| SCHEMBL30710500 | 0.84 | TRPM8 (0.41) | NR1H2UCHL1USP30TRPV1 | |
| SCHEMBL29560706 | 0.83 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL29405461 | 0.83 | NR1H2 (0.43) | TP53HDAC1HDAC6NR1H2UCHL1 | |
| SCHEMBL30734235 | 0.80 | ESR1 (0.51) | LMNAGHSRTRPV1TSHRESR2 | |
| SCHEMBL30734308 | 0.80 | ESR1 (0.51) | LMNAGHSRTRPV1TSHRESR2 | |
| SCHEMBL27276906 | 0.80 | ESR1 (0.51) | LMNAGHSRTRPV1TSHRESR2 | |
| SCHEMBL30710294 | 0.78 | NR1H2 (0.42) | LMNAHDAC1HDAC6NR1H2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |