SCHEMBL30717643

SCHEMBL30717643

CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1nc2c(s1)CN(C(=O)C(F)(F)F)CC2(C)C

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.37
GPR119 Q8TDV5 1/20 0.34
USP30 Q70CQ3 1/20 0.31
ADORA1 P30542 2/20 0.31
LIPE Q05469 1/20 0.30
DDB1 Q16531 1/20 0.30
CRBN Q96SW2 1/20 0.30
RORC P51449 5/20 0.30
RET P07949 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30717635 0.88
SCHEMBL30717589 0.83 IL1B (0.36) NR1H2GPR119USP30DDB1CRBN
SCHEMBL30717613 0.81 GRAMD1A (0.41) GPR119USP30ADORA1LIPE
SCHEMBL30717657 0.79 ADORA1 (0.35) GPR119USP30ADORA1LIPERET
SCHEMBL30717580 0.79 DDB1 (0.36) NR1H2GPR119USP30DDB1CRBN
SCHEMBL30717624 0.74 GPR119 (0.40) GPR119USP30RORC
SCHEMBL19549758 0.74 NR1H2 (0.47) NR1H2ADORA1RORC
SCHEMBL19549752 0.73 NR1H2 (0.46) NR1H2GPR119ADORA1
SCHEMBL30686635 0.73 NR1H2 (0.44) NR1H2GPR119ADORA1
SCHEMBL30717715 0.72 DDB1 (0.35) NR1H2GPR119USP30DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 EP disclosed
WO-2024038128-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2024-02-22 WO disclosed