Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21793869 | 1.00 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL15850502 | 0.84 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL30107670 | 0.84 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL21777625 | 0.83 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL31503559 | 0.82 | SMN1; SMN2 (0.67) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL28534153 | 0.82 | SMN1; SMN2 (0.67) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL21793877 | 0.81 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL30723189 | 0.81 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL30665751 | 0.77 | BCHE (0.63) | NPC1RAB9ASMN1; SMN2TLR9KDR | |
| SCHEMBL27323740 | 0.77 | BCHE (0.63) | NPC1RAB9ASMN1; SMN2TLR9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2024-05-16 | — | — | US | disclosed |
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | SQSTM1, HSPA5, ATG7 | NPC1 151/4885RAB9A 299/4885SMN1; SMN2 2417/4885 |
| US-20240156872-A1 | Use of Chaperone-Mediated Autophagy Activators For Treating Or Preventing Blood Cancers And Myelodysplastic Syndromes And Enriching Hematopoietic Stem Cell Populations | SQSTM1, MCL1, HSPA2 | NPC1 1454/4885RAB9A 701/4885SMN1; SMN2 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.