Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | EML4 | Q9HC35 | 6/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.37 |
| ▸ | RET | P07949 | 5/20 | 0.36 |
| ▸ | ROS1 | P08922 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30310881 | 0.90 | KDM4E (0.41) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL27038486 | 0.89 | KDM4E (0.40) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL24074321 | 0.87 | KDM4E (0.47) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL21280381 | 0.82 | MAPT (0.47) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL17264115 | 0.80 | ALDH1A1 (0.46) | KDM4EMAPTRAD52ALDH1A1HTT | |
| SCHEMBL28313862 | 0.79 | ALDH1A1 (0.51) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL16640698 | 0.78 | MAPT (0.49) | KDM4EMAPTRAD52ALDH1A1HTT | |
| SCHEMBL10036441 | 0.77 | MAPT (0.70) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL10035939 | 0.77 | MAPT (0.56) | KDM4EMAPTRAD52EML4ALK | |
| SCHEMBL30730929 | 0.77 | EML4 (0.43) | KDM4EMAPTRAD52EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024017258-A1 | EGFR SMALL MOLECULE INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | 百极弘烨(南通)医药科技有限公司 | 2024-01-25 | — | — | WO | disclosed |