Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | DTYMK | P23919 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653185 | 0.87 | P2RX7 (0.55) | SMARCA2SMARCA4PBRM1MAPK1ESR2 | |
| SCHEMBL1663013 | 0.86 | P2RX7 (0.56) | MAPK1P2RX7 | |
| SCHEMBL30734152 | 0.86 | MEN1 (0.51) | SMN1; SMN2MAPK1NR1H2P2RX7MAPT | |
| SCHEMBL1583488 | 0.86 | MEN1 (0.51) | SMN1; SMN2MAPK1NR1H2P2RX7MAPT | |
| SCHEMBL2604325 | 0.84 | MAPK1 (0.44) | SMARCA2SMARCA4PBRM1MAPK1ESR2 | |
| SCHEMBL2604326 | 0.84 | PDE4B (0.44) | MAPK1ESR2NR1H2PDE4BPDE7A | |
| SCHEMBL1583986 | 0.83 | GPR119 (0.44) | SMARCA2SMARCA4PBRM1MAPK1NR1H2 | |
| SCHEMBL3068738 | 0.83 | GPR119 (0.53) | MAPK1ESR2NR1H2GPR119DTYMK | |
| SCHEMBL2382922 | 0.81 | GAA (0.69) | SMARCA2SMARCA4PBRM1GAASMN1; SMN2 | |
| SCHEMBL30613376 | 0.81 | GAA (0.69) | SMARCA2SMARCA4PBRM1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052380-A1 | Inhibitors of prenyl-protein transferase | DINSMORE CHRISTOPHER J (US) | 2002-05-02 | — | — | US | disclosed |
| US-20020010184-A1 | Inhibitors of prenyl-protein transferase | DINSMORE CHRISTOPHER J (US) | 2002-01-24 | — | — | US | disclosed |
| WO-2001060368-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-08-23 | — | — | WO | disclosed |
| WO-2001060815-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-08-23 | — | — | WO | disclosed |
| US-6103723-A | INHIBIT FARNESYL-PROTEIN TRANSFERASE (FTASE) AND THE FARNESYLATION OF THE ONCOGENE PROTEIN RAS; ANTICARCINOGENIC AGENTS; CONFORMATIONALLY CONSTRAINED COMPOUNDS THAT DO NOT HAVE A THIOL MOIETY; INHIBITION OF POST-TRANSLATIONAL | MERCK & CO., INC. (US) | 2000-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010184-A1 | Inhibitors of prenyl-protein transferase | FNTA, FNTB, ZMPSTE24 | SMARCA2 3685/4885SMARCA4 3047/4885PBRM1 1643/4885 |
| US-20020052380-A1 | Inhibitors of prenyl-protein transferase | FNTA, FNTB, GGPS1 | SMARCA2 3748/4885SMARCA4 3220/4885PBRM1 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.