Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 4/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146976 | 1.00 | NR3C2 (0.35) | NR3C2PARP1ARLOXLOXL2 | |
| SCHEMBL31440248 | 0.86 | PARP1 (0.36) | NR3C2PARP1ARLOXLOXL2 | |
| SCHEMBL17000172 | 0.85 | GABRA1 (0.40) | NR3C2PARP1ARLOXLOXL2 | |
| SCHEMBL15911399 | 0.81 | PNMT (0.46) | SLC6A2HTR2AHTR2BSLC6A3 | |
| SCHEMBL12633376 | 0.78 | NOS2 (0.58) | NR3C2GABRA1GABRB2NOS2KDM4E | |
| SCHEMBL25305878 | 0.77 | KDM6B (0.51) | NR3C2PARP1ARGABRA1GABRB2 | |
| SCHEMBL29183400 | 0.76 | AR (0.33) | PARP1ARLOXLOXL2 | |
| SCHEMBL29183405 | 0.76 | AR (0.33) | PARP1ARLOXLOXL2 | |
| SCHEMBL18674835 | 0.75 | NR3C2 (0.34) | NR3C2ALOX12KDM4EALOX5 | |
| SCHEMBL648113 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260028352-A1 | MACROCYCLIC IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | SUZHOU LANGRUI BIOPHARMACEUTICAL CO LTD (CN) | 2026-01-29 | — | — | US | disclosed |
| EP-4585598-A1 | MACROCYCLIC IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Suzhou Langrui Biopharmaceutical Co., Ltd. (CN) | 2025-07-16 | — | — | EP | disclosed |
| CN-117659020-A | Imidazo [1,2-b ] pyridazine derivative, and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117659043-A | Macrocyclic imidazo [1,2-b ] pyridazine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-03-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260028352-A1 | MACROCYCLIC IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | WEE2, WEE1, ROR1 | NR3C2 190/4885PARP1 2815/4885AR 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.