Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144449 | 1.00 | GABRR1 (0.39) | GABRR1GABBR2GABBR1 | |
| SCHEMBL3061777 | 0.80 | — | — | |
| SCHEMBL3056223 | 0.80 | — | — | |
| SCHEMBL3056222 | 0.80 | — | — | |
| SCHEMBL1681004 | 0.78 | CHRM1 (0.39) | — | |
| SCHEMBL3056305 | 0.77 | GABRR1 (0.37) | GABRR1GABBR2GABBR1 | |
| SCHEMBL18281192 | 0.76 | DPP7 (0.40) | GABRR1GABBR2GABBR1 | |
| SCHEMBL18281190 | 0.76 | DPP7 (0.40) | GABRR1GABBR2GABBR1 | |
| SCHEMBL11494381 | 0.74 | GPR84 (0.34) | — | |
| SCHEMBL1681272 | 0.74 | GPR84 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| EP-1893194-A4 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1893194-A1 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006127961-A1 | ENHANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | GABRR1 1997/4885GABBR2 3012/4885GABBR1 2931/4885 |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, PRKCH | GABRR1 1608/4885GABBR2 3192/4885GABBR1 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.