Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30744879 | 0.80 | KDM4E (0.51) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL30744751 | 0.79 | KDM4E (0.59) | KDM4EIGFBP5ALOX15IGFBP3 | |
| SCHEMBL30744853 | 0.78 | ADORA2A (0.46) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL3333164 | 0.78 | GRM2 (0.48) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL13977964 | 0.78 | AURKA (0.59) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL8114876 | 0.77 | GPR35 (0.54) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL13857985 | 0.77 | AURKA (0.51) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL30421043 | 0.76 | ALOX15 (0.62) | GRM2KDM4EAURKAADORA2AADORA1 | |
| SCHEMBL17583090 | 0.75 | GRM2 (0.46) | GRM2ADORA2AADORA1ALOX15TACR3 | |
| SCHEMBL6080305 | 0.75 | BID (0.56) | KDM4EHCAR2PPARGALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111295382-B | Bridged bicyclic compounds as farnesyl ester X receptor modulators | 百时美施贵宝公司 | 2024-02-02 | — | — | CN | claimed |
| CN-111295382-B | Bridged bicyclic compounds as farnesyl ester X receptor modulators | 百时美施贵宝公司 | 2024-02-02 | — | — | CN | disclosed |