Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | BACE1 | P56817 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745479 | 0.91 | APP (0.52) | ACHEBACE1HDAC3HDAC1HDAC2 | |
| SCHEMBL30745475 | 0.90 | ABCG2 (0.52) | ACHEBACE1HDAC3HDAC1HDAC2 | |
| SCHEMBL30745466 | 0.89 | MAOA (0.53) | HDAC3HDAC1HDAC2HDAC8APP | |
| SCHEMBL30745477 | 0.81 | HDAC3 (0.55) | ACHEBACE1HDAC3HDAC1HDAC2 | |
| SCHEMBL25239854 | 0.79 | ACHE (0.81) | ACHEBACE1CTSLTUBB4ATUBB | |
| SCHEMBL30745430 | 0.79 | ACHE (0.67) | ACHEBACE1CTSLTUBB4ATUBB | |
| SCHEMBL30745488 | 0.79 | ACHE (0.65) | ACHEBACE1CTSLAPPTUBB4A | |
| SCHEMBL29011908 | 0.76 | ACHE (0.76) | ACHEBACE1CTSLAPPTUBB4A | |
| SCHEMBL30745514 | 0.75 | ACHE (0.61) | ACHEBACE1CTSLAPPMAOB | |
| SCHEMBL30745510 | 0.75 | ABCG2 (0.53) | ACHEBACE1ARMAOBABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |