SCHEMBL30748860

SCHEMBL30748860

CCCNc1nc(CO[Si](C)(C)C(C)(C)C)nc2c1C(C)(C)C(=O)N2c1ccc(N2CCOCC2)cc1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAD52 P43351 1/20 0.33
SYK P43405 7/20 0.32
TLR7 Q9NYK1 1/20 0.32
AGXT P21549 1/20 0.31
BRD4 O60885 2/20 0.31
MAPT P10636 2/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPK1 P28482 1/20 0.31
CDK4 P11802 1/20 0.30
CCND1 P24385 1/20 0.30
FLT3 P36888 1/20 0.30
TYRO3 Q06418 1/20 0.30
MERTK Q12866 1/20 0.30
GAS6 Q14393 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NTRK1 P04629 1/20 0.30
ADORA3 P0DMS8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749058 0.93 ADORA3 (0.36) SYKAGXTMAPTALDH1A1MAPK1
SCHEMBL31691354 0.90 AGXT (0.33) SYKAGXTBRD4MAPTALDH1A1
SCHEMBL30749048 0.89 NTRK1 (0.31) SYKAGXTMAPTALDH1A1MAPK1
SCHEMBL30748976 0.87 SYK (0.36) SYKAGXTALDH1A1
SCHEMBL30748935 0.85 AGXT (0.37) TLR7AGXTBRD4MAPTALDH1A1
SCHEMBL30748952 0.85 SYK (0.37) RAD52SYKTLR7BRD4MAPT
SCHEMBL30748783 0.84 AGXT (0.34) AGXTMAPTALDH1A1FLT3
SCHEMBL30748893 0.78 MAOB (0.37) SYKALDH1A1FLT3
SCHEMBL30749038 0.78 ADORA3 (0.39) SYKMAPTALDH1A1MAPK1NPC1
SCHEMBL30748939 0.77 TRPV1 (0.33) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT RAD52 3673/4885SYK 2316/4885TLR7 2372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.