SCHEMBL30748976

SCHEMBL30748976

CC(C)Nc1nc(CO[Si](C)(C)C(C)(C)C)nc2c1C(C)(C)C(=O)N2c1ccc(N2CCOCC2)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SYK P43405 6/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
LRRK2 Q5S007 3/20 0.33
CSF1R P07333 1/20 0.33
PDGFRA P16234 1/20 0.33
ALDH1A1 P00352 3/20 0.32
MRGPRX4 Q96LA9 1/20 0.32
AGXT P21549 1/20 0.32
CYP3A4 P08684 2/20 0.31
KDM4E B2RXH2 1/20 0.31
MDM2 Q00987 1/20 0.31
BTK Q06187 1/20 0.31
GPR139 Q6DWJ6 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31691354 0.91 AGXT (0.33) SYKL3MBTL1LRRK2ALDH1A1MRGPRX4
SCHEMBL30749058 0.89 ADORA3 (0.36) SYKL3MBTL1ALDH1A1MRGPRX4AGXT
SCHEMBL30749048 0.88 NTRK1 (0.31) SYKL3MBTL1LRRK2ALDH1A1AGXT
SCHEMBL30748860 0.87 RAD52 (0.33) SYKALDH1A1AGXT
SCHEMBL30748935 0.86 AGXT (0.37) ALDH1A1MRGPRX4AGXTKDM4ETSHR
SCHEMBL30748933 0.86 SYK (0.40) SYKL3MBTL1LRRK2CSF1RPDGFRA
SCHEMBL30748783 0.85 AGXT (0.34) L3MBTL1ALDH1A1MRGPRX4AGXTCYP3A4
SCHEMBL31691331 0.79 SYK (0.36) SYK
SCHEMBL31691204 0.79 SYK (0.32) SYKL3MBTL1ALDH1A1MDM2
SCHEMBL31691365 0.79 MAPT (0.33) L3MBTL1LRRK2ALDH1A1AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT SYK 2316/4885L3MBTL1 517/4885LRRK2 4090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.