SCHEMBL30749048

SCHEMBL30749048

CC1(C)C(=O)N(c2ccc(N3CCOCC3)cc2)c2nc(CO[Si](C)(C)C(C)(C)C)nc(NCC(F)F)c21

nearest known ligand 0.31

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
AGXT P21549 1/20 0.31
SYK P43405 2/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
MAPK1 P28482 1/20 0.30
LRRK2 Q5S007 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749058 0.90 ADORA3 (0.36) NTRK1L3MBTL1AGXTSYKALDH1A1
SCHEMBL30748860 0.89 RAD52 (0.33) NTRK1AGXTSYKALDH1A1MAPT
SCHEMBL31691354 0.88 AGXT (0.33) NTRK1L3MBTL1AGXTSYKALDH1A1
SCHEMBL31691413 0.88 TRPV1 (0.31) LRRK2
SCHEMBL30748976 0.88 SYK (0.36) L3MBTL1AGXTSYKALDH1A1LRRK2
SCHEMBL30749016 0.86 SYK (0.36) NTRK1L3MBTL1SYKALDH1A1
SCHEMBL30748935 0.84 AGXT (0.37) AGXTALDH1A1MAPTMAPK1
SCHEMBL30748783 0.83 AGXT (0.34) L3MBTL1AGXTALDH1A1MAPT
SCHEMBL30748893 0.79 MAOB (0.37) SYKALDH1A1
SCHEMBL31691226 0.78 TNKS (0.30) AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT NTRK1 4248/4885L3MBTL1 517/4885AGXT 955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.