SCHEMBL30748902

SCHEMBL30748902

CNc1nc(CO)nc2c1C(C)(C)C(=O)N2c1ccc(N2CCC(F)(F)CC2)nc1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPV3 Q8NET8 2/20 0.35
DGAT1 O75907 1/20 0.34
ADRA1A P35348 1/20 0.33
HTR1A P08908 2/20 0.32
PTPN11 Q06124 1/20 0.32
SYK P43405 2/20 0.31
HRH3 Q9Y5N1 1/20 0.31
CRBN Q96SW2 1/20 0.31
CACNA1H O95180 2/20 0.31
LRRK2 Q5S007 1/20 0.31
BCL6 P41182 1/20 0.30
CHRM4 P08173 1/20 0.30
NAPEPLD Q6IQ20 1/20 0.30
WEE1 P30291 1/20 0.30
ACACB O00763 1/20 0.30
PTGER4 P35408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31691233 0.85 DGAT1 (0.34) DGAT1
SCHEMBL30748745 0.85 ACACB (0.35) TRPV3SYKACACB
SCHEMBL30748735 0.83 AOC3 (0.36) ADRA1ASYKLRRK2BCL6
SCHEMBL30748932 0.82 TRPV1 (0.35) SYKHRH3CACNA1H
SCHEMBL30749022 0.78 AOC3 (0.34) ADRA1ASYK
SCHEMBL30748787 0.78 L3MBTL1 (0.36) SYKLRRK2
SCHEMBL30749146 0.78 ADRA1A (0.35) TRPV3DGAT1ADRA1ACRBNACACB
SCHEMBL30748989 0.75 ACACB (0.39) HRH3LRRK2CHRM4ACACB
SCHEMBL30748728 0.75 BTK (0.35) ADRA1ASYKLRRK2
SCHEMBL30749150 0.75 SYK (0.41) TRPV3ADRA1ASYKACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT TRPV3 1971/4885DGAT1 1487/4885ADRA1A 4106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.