SCHEMBL30748745

SCHEMBL30748745

CNc1nc(CO)nc2c1C(C)(C)C(=O)N2c1cnc(N2CCC(F)(F)C2)nc1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACACB O00763 6/20 0.35
TRPV3 Q8NET8 1/20 0.33
PDE10A Q9Y233 1/20 0.33
CNR2 P34972 1/20 0.31
SYK P43405 2/20 0.31
DPP4 P27487 1/20 0.30
GBA1 P04062 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749150 0.89 SYK (0.41) ACACBTRPV3PDE10ACNR2SYK
SCHEMBL31691369 0.85 ACACB (0.33) ACACBCNR2
SCHEMBL30748902 0.85 TRPV3 (0.35) ACACBTRPV3SYK
SCHEMBL30748916 0.81 HDAC6 (0.34) SYK
SCHEMBL30749136 0.77 ACACB (0.37) ACACBPDE10ACNR2DPP4
SCHEMBL30748787 0.74 L3MBTL1 (0.36) SYK
SCHEMBL31691238 0.73 ACACB (0.34) ACACBPDE10ACNR2
SCHEMBL30748735 0.72 AOC3 (0.36) SYK
SCHEMBL30748929 0.72 ALOX15 (0.33) SYK
SCHEMBL31691334 0.71 HDAC6 (0.34) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT ACACB 1127/4885TRPV3 1971/4885PDE10A 1621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.