SCHEMBL30748990

SCHEMBL30748990

C[C@@H]1C[C@H](C)CN(c2ncc(N3C(=O)C(C)(C)c4c(Cl)nc(Cl)nc43)cc2F)C1

nearest known ligand 0.31

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.31
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748995 0.88 NPC1 (0.37) NPC1ALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL30748943 0.83
SCHEMBL30748737 0.75
SCHEMBL30748931 0.74 PDE3B (0.41) MEN1GAATSHRKMT2ANPC1
SCHEMBL31691210 0.73 MAPK14 (0.35) GAAKMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL30748805 0.71 KMT2A (0.39) KMT2ANPC1RAB9ASMN1; SMN2MAPT
SCHEMBL30748801 0.70 ELANE (0.37) GAATSHRKMT2ANPC1ALDH1A1
SCHEMBL30748904 0.69 RAD51 (0.42) NPC1ALDH1A1HPGDSMN1; SMN2
SCHEMBL30749136 0.69 ACACB (0.37)
SCHEMBL30749007 0.65 ELANE (0.44) KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT MEN1 301/4885GAA 84/4885TSHR 4739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.