Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 11/20 | 1.00 |
| ▸ | MAP3K9 | P80192 | 10/20 | 1.00 |
| ▸ | PRKCA | P17252 | 5/20 | 1.00 |
| ▸ | MAP3K10 | Q02779 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 4/20 | 1.00 |
| ▸ | PRKCG | P05129 | 4/20 | 1.00 |
| ▸ | PRKCB | P05771 | 4/20 | 1.00 |
| ▸ | PRKCH | P24723 | 4/20 | 1.00 |
| ▸ | PRKCI | P41743 | 4/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 4/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 4/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 4/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 4/20 | 1.00 |
| ▸ | PRKD1 | Q15139 | 4/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 2/20 | 1.00 |
| ▸ | GLI1 | P08151 | 1/20 | 0.66 |
| ▸ | GLI2 | P10070 | 1/20 | 0.66 |
| ▸ | CDK4 | P11802 | 1/20 | 0.66 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082217 | 0.90 | MAP3K9 (1.00) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL6629443 | 0.87 | MAP3K9 (0.76) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL6627111 | 0.87 | MAP3K9 (0.76) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL6628810 | 0.87 | MAP3K11 (0.76) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL3268039 | 0.87 | MAP3K9 (0.76) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL3268623 | 0.85 | MAP3K9 (0.73) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL14494154 | 0.84 | KDR (0.74) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL14494184 | 0.84 | MAP3K9 (0.72) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL3075228 | 0.82 | MAP3K9 (0.80) | MAP3K11MAP3K9PRKCAMAP3K10KDR | |
| SCHEMBL14494163 | 0.82 | MAP3K9 (0.69) | MAP3K11MAP3K9PRKCAMAP3K10KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410267-B2 | Regioselective reduction of fused pyrrolocarbazoles-5,7-diones | TEVA SANTE (FR) | 2013-04-02 | — | — | US | disclosed |
| US-8383813-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120004253-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-8044064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-8044064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110224436-A1 | REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES | CEPHALON FRANCE (FR) | 2011-09-15 | — | — | US | disclosed |
| US-7789610-B2 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7789610-B2 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7789610-B2 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-7169802-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169802-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1088823-B1 | Fused pyrrolocarbazoles | CEPHALON INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1126855-A4 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6448283-B1 | FUSED PYRROLOCARBAZOLES; HEARING LOSS AND LOSS OF THE SENSE OF BALANCE | CEPHALON, INC. | 2002-09-10 | — | — | US | disclosed |
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | CEPHALON, INC. | 2002-08-22 | — | — | US | disclosed |
| EP-0785938-B1 | FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1126855-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000018407-A1 | METHODS FOR PREVENTING/TREATING DAMAGE TO SENSORY HAIR CELLS AND COCHLEAR NEURONS | CEPHALON, INC. (US) | 2000-04-06 | — | — | WO | disclosed |
| US-5591855-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | PC, PYCR1, CYP11B2 | MAP3K11 3535/4885MAP3K9 3651/4885PRKCA 2189/4885 |
| US-20120004253-A1 | Novel Fused Pyrrolocarbazoles | PC, PYCR1, CYP11B2 | MAP3K11 3535/4885MAP3K9 3651/4885PRKCA 2189/4885 |
| US-20020115706-A1 | Methods for preventing/treating damage to sensory hair cells and cochlear neurons | GJB2, GAP43, MYOC | MAP3K11 2895/4885MAP3K9 2839/4885PRKCA 1259/4885 |
| US-20110224436-A1 | REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES | CYP51A1, DHPS, PRMT7 | MAP3K11 1596/4885MAP3K9 2177/4885PRKCA 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.