Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 14/20 | 0.44 |
| ▸ | MMP1 | P03956 | 9/20 | 0.44 |
| ▸ | MMP3 | P08254 | 9/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30759489 | 0.95 | OPRM1 (0.48) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL30759468 | 0.89 | OPRM1 (0.45) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL30759345 | 0.86 | KISS1R (0.44) | OPRM1OPRD1MMP2MMP1 | |
| SCHEMBL8583007 | 0.81 | MME (0.64) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL30973624 | 0.81 | MME (0.64) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL9956195 | 0.81 | MME (0.64) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL30555017 | 0.78 | MME (0.60) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL29498151 | 0.78 | BIRC2 (0.62) | OPRM1OPRD1HDAC3HDAC4HDAC1 | |
| SCHEMBL30759473 | 0.77 | MMP2 (0.43) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL30411712 | 0.77 | OPRK1 (0.42) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
| EP-4558513-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | Merck Sharp & Dohme LLC (US) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | OPRM1 2520/4885OPRD1 2249/4885HDAC3 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.