Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765785 | 0.88 | KDM4E (0.40) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL30765705 | 0.83 | ALDH1A1 (0.38) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL23460591 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1F2POLBASPH | |
| SCHEMBL30765933 | 0.78 | KDM4C (0.45) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL30765644 | 0.77 | KDM4E (0.42) | KDM4EALDH1A1F2POLBASPH | |
| SCHEMBL23474380 | 0.77 | KDM4E (0.41) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL30765612 | 0.75 | KDM4E (0.44) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL23461141 | 0.73 | KDM4E (0.46) | JAK2JAK1JAK3KDM4EALDH1A1 | |
| SCHEMBL30765741 | 0.72 | LMNA (0.41) | KDM4EALDH1A1POLBLMNAHTT | |
| SCHEMBL23461175 | 0.69 | ALDH1A1 (0.42) | JAK2JAK1JAK3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568666-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Alexion Pharmaceuticals, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024035686-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-15 | — | — | WO | disclosed |