Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898835 | 1.00 | LMNA (0.59) | LMNATHRBPTGESATMALDH1A1 | |
| SCHEMBL15835213 | 0.86 | SLC27A1 (0.48) | LMNATHRBPTGESATMALDH1A1 | |
| SCHEMBL14970840 | 0.74 | TP53 (0.71) | THRBPTGESALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL18559341 | 0.72 | ATM (1.00) | LMNATHRBPTGESATMALDH1A1 | |
| SCHEMBL14970814 | 0.72 | SMN1; SMN2 (0.71) | LMNATHRBPTGESATMALDH1A1 | |
| SCHEMBL18559152 | 0.72 | GAA (0.84) | LMNAATMALDH1A1GAATP53 | |
| SCHEMBL18559258 | 0.71 | ALDH1A1 (1.00) | THRBPTGESATMALDH1A1GAA | |
| SCHEMBL29327531 | 0.70 | ALDH1A1 (0.60) | PTGESATMALDH1A1GAATP53 | |
| SCHEMBL14970841 | 0.69 | THRB (0.68) | LMNATHRBPTGESATMALDH1A1 | |
| SCHEMBL4209247 | 0.69 | ALDH1A1 (0.68) | LMNAPTGESALDH1A1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024037910-A1 | SYK INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Institut National de la Santé et de la Recherche Médicale (FR) | 2024-02-22 | — | — | WO | disclosed |