SCHEMBL30801460

SCHEMBL30801460

COC(=O)C(F)(F)Cc1ccc(C)cc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 3/20 0.44
PTPRB P23467 2/20 0.42
TDP1 Q9NUW8 1/20 0.41
RAB9A P51151 3/20 0.40
NPC1 O15118 3/20 0.40
NR3C1 P04150 1/20 0.40
HPGD P15428 1/20 0.40
TP53 P04637 1/20 0.40
PTPN2 P17706 1/20 0.39
PTPRA P18433 1/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
KMT2A Q03164 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11533573 0.84 CTRB1 (0.51) PTPN1PTPRBPTPN2PTPRASMN1; SMN2
SCHEMBL11530777 0.80 HPGD (0.45) PTPN1PTPRBTDP1RAB9ANPC1
SCHEMBL11531882 0.77 HPGD (0.50) PTPN1PTPRBTDP1RAB9ANPC1
SCHEMBL27188914 0.76 MMP8 (0.47) PTPN1PTPRBTDP1RAB9ANPC1
SCHEMBL28033792 0.74 HDAC4 (0.47) RAB9ANPC1SMN1; SMN2NPSR1LMNA
SCHEMBL3912206 0.73 ALDH1A1 (0.53) PTPRBTDP1RAB9ANPC1HPGD
SCHEMBL3920792 0.72 ESR1 (0.47) KMT2ANPSR1MEN1GAALMNA
SCHEMBL3629075 0.72 LMNA (0.50) RAB9ANPC1SMN1; SMN2KMT2ANPSR1
SCHEMBL12266062 0.72 CA2 (0.40) RAB9ANPC1HPGDSMN1; SMN2KMT2A
SCHEMBL2756353 0.71 PTPRB (0.56) PTPRBHPGDSMN1; SMN2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117550987-A Method for synthesizing beta-amino acid compound based on alkene nitrogen carboxylation reaction 四川大学 2024-02-13 CN disclosed