Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305704 | 0.88 | MAPT (0.39) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL306001 | 0.76 | MAPT (0.40) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL5569866 | 0.74 | POLB (0.44) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL4776729 | 0.71 | MAPT (0.46) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL125850 | 0.70 | POLB (0.44) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL10222830 | 0.69 | MAPT (0.36) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL125851 | 0.69 | MAPT (0.42) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL12594275 | 0.68 | LMNA (0.44) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL306111 | 0.68 | MAPT (0.40) | MAPTALDH1A1L3MBTL1LMNAPTGDR2 | |
| SCHEMBL305705 | 0.67 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093247-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100056509-A1 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056509-A1 | HETEROARYL SULFONAMIDES AND CCR2 | CCR2, CXCR2, CCR1 | MAPT 4602/4885ALDH1A1 2327/4885L3MBTL1 2304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.