Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | ADH5 | P11766 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24677008 | 1.00 | PDE3B (0.44) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL30833286 | 0.78 | EGLN2 (0.39) | CRBNCYP11B1CYP11B2CYP3A4LMNA | |
| SCHEMBL30833285 | 0.74 | CYP1A2 (0.35) | CYP3A4LMNA | |
| SCHEMBL31048001 | 0.71 | NOTUM (0.45) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL30099722 | 0.69 | GABRA1 (0.48) | GABRG2GABRB3GABRA5LMNA | |
| SCHEMBL30833278 | 0.69 | CASP3 (0.57) | GABRG2GABRB3GABRA5LMNA | |
| SCHEMBL7273296 | 0.68 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL29769797 | 0.68 | CD38 (0.35) | CRBNCYP3A4LMNA | |
| SCHEMBL27294863 | 0.67 | CYP19A1 (0.53) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL23137976 | 0.67 | PDE3B (0.56) | PDE3BPDE3ACRBNTBXAS1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117580829-A | Quinoline and azaquinolines as inhibitors of CD38 | 勃林格英格翰国际有限公司 | 2024-02-20 | — | — | CN | disclosed |