Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABHD11 | Q8NFV4 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17942365 | 0.81 | GPR119 (0.45) | ATM | |
| SCHEMBL30833434 | 0.78 | MEN1 (0.42) | PDE8BTRPV1NPC1RAB9AKDM1A | |
| SCHEMBL29262265 | 0.77 | ALDH1A1 (0.50) | NPC1RAB9AKMT2ANLRP3 | |
| SCHEMBL30833410 | 0.77 | GPR119 (0.45) | PDE8BTRPV1NPC1RAB9AKDM1A | |
| SCHEMBL30833390 | 0.76 | OPRD1 (0.44) | TRPV1NPC1RAB9AKDM1AMEN1 | |
| SCHEMBL30833473 | 0.76 | GPR119 (0.42) | PDE8BTRPV1NPC1RAB9AKDM1A | |
| SCHEMBL30833395 | 0.75 | APP (0.46) | NPC1RAB9AKDM1AMEN1KMT2A | |
| SCHEMBL1763583 | 0.75 | LMNA (0.47) | NPC1RAB9AMEN1KMT2AAPP | |
| SCHEMBL1763578 | 0.75 | LMNA (0.47) | NPC1RAB9AMEN1KMT2AAPP | |
| SCHEMBL30833510 | 0.74 | PDE8B (0.40) | PDE8BNPC1RAB9AKDM1AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |