Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833453 | 0.82 | WNT3 (0.38) | WNT3SFRP1MEN1KMT2AALDH1A1 | |
| SCHEMBL30833382 | 0.81 | SFRP1 (0.38) | NPC1WNT3SFRP1MEN1KMT2A | |
| SCHEMBL17942546 | 0.81 | TGFBR1 (0.44) | — | |
| SCHEMBL30833484 | 0.80 | PDE8B (0.39) | KDM1APDE8BATMTRPV1CHEK2 | |
| SCHEMBL30833454 | 0.80 | KMT2A (0.40) | PDE8BTRPV1WNT3SFRP1MEN1 | |
| SCHEMBL30833443 | 0.80 | TRPV1 (0.40) | KDM1APDE8BATMNPC1RAB9A | |
| SCHEMBL30833401 | 0.78 | KDM1A (0.44) | KDM1APDE8BATMNPC1RAB9A | |
| SCHEMBL30833390 | 0.78 | OPRD1 (0.44) | KDM1ANPC1RAB9ATRPV1APP | |
| SCHEMBL30833510 | 0.76 | PDE8B (0.40) | KDM1APDE8BATMNPC1RAB9A | |
| SCHEMBL30833395 | 0.75 | APP (0.46) | KDM1ANPC1RAB9AAPPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164961-A | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-111393414-B | 4-Methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2024-05-07 | — | — | CN | disclosed |