⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26345537 | 0.70 | — | — | |
| SCHEMBL10534630 | 0.70 | — | — | |
| SCHEMBL27363958 | 0.65 | KIF11 (0.35) | — | |
| SCHEMBL7039375 | 0.65 | — | — | |
| SCHEMBL8800733 | 0.65 | — | — | |
| SCHEMBL3361203 | 0.64 | NOTUM (0.44) | — | |
| Dalfampridine SCHEMBL53483 | 0.62 | — | — | |
| Dalfampridine SCHEMBL1442620 | 0.62 | MAPT (1.00) | — | |
| SCHEMBL3606842 | 0.60 | — | — | |
| Dalfampridine SCHEMBL7987482 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858322-B2 | Process for preparing 1-isobutyryl-1′-((1-(4,4,4-trifluorobutyl)-4,5,6,7-tetrahydro-1H-benzo[D]imidazol-2-yl)methyl)spiro[azetidine-3,3′-indolin]-2′-one | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-12-08 | — | — | US | disclosed |
| EP-3305790-B1 | METHOD FOR PREPARING IMIDAZOLE DERIVATIVE AND INTERMEDIATE THEREOF AND CRYSTAL FORM | SHANGDONG DANHONG PHARMACEUTICAL CO LTD (CN) | 2020-08-05 | — | — | EP | disclosed |
| US-20200223802-A1 | PROCESS FOR PREPARING 1-ISOBUTYRYL-1'-((1-(4,4,4-TRIFLUORO-BUTYL)-4,5,6,7- TETRAHYDRO-1H-BENZO[D]IMIDAZOL-2-YL)METHYL)SPIRO[AZETIDINE-3,3'-INDOLIN]-2'-ONE | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-07-16 | — | — | US | disclosed |
| US-10633347-B2 | Crystal form B of 1-isobutyryl-1′-((1-(4,4,4-trifluorobutyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazol-2-yl)methyl)spiro[azetidine-3,3′-indolin]-2′-one | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-04-28 | — | — | US | disclosed |
| US-20190218189-A1 | CRYSTAL FORM A OF 1-ISOBUTYRYL-1'-((1-(4,4,4-TRIFLUOROBUTYL)-4,5,6,7-TETRAHYDRO-1H-BENZO[D]IMIDAZOL-2-YL)METHYL)SPIRO[AZETIDINE-3,3'-INDOLIN]-2'-ONE | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2019-07-18 | — | — | US | disclosed |
| US-10227309-B2 | Crystal form A of 1-isobutyryl-1′-((1-(4,4,4-trifluorobutyl)-4,5,6,7-tetrahydro-1H-benzo [d]imidazol-2-yl)methyl)spiro[azetidine-3,3′-indolin]-2′-one | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2019-03-12 | — | — | US | disclosed |
| US-20180179166-A1 | SMALL MOLECULE INHIBITORS OF GP120-MEDIATED HIV INFECTION AND METHODS OF USE | VIROCARB INC (CA) | 2018-06-28 | — | — | US | disclosed |
| US-20180141915-A1 | METHOD FOR PREPARING IMIDAZOLE DERIVATIVE AND INTERMEDIATE THEREOF AND CRYSTAL FORM | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| EP-3305790-A1 | METHOD FOR PREPARING IMIDAZOLE DERIVATIVE AND INTERMEDIATE THEREOF AND CRYSTAL FORM | Shangdong Danhong Pharmaceutical Co., Ltd. (CN) | 2018-04-11 | — | — | EP | disclosed |
| WO-2015143535-A1 | SMALL MOLECULE INHIBITORS OF GP120-MEDIATED HIV INFECTION AND METHODS OF USE | VIROCARB INC. (CA) | 2015-10-01 | — | — | WO | disclosed |
| US-6506738-B1 | Treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection. | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-14 | — | — | US | disclosed |
| WO-2002102769-A2 | METHODS FOR SYNTHESIZING SUBSTITUTED PYRIMIDINES | UNIVERSITY OF MASSACHUSETTS (US) | 2002-12-27 | — | — | WO | disclosed |
| US-6489338-B2 | TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTION. | BRISTOL-MYERS SQUIBB COMPANY | 2002-12-03 | — | — | US | disclosed |
| WO-2002062290-A2 | HETEROCYCLIC SUBSTITUTED 2-METHYL-BENZIMIDAZOLE ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-15 | — | — | WO | disclosed |
| US-20020099208-A1 | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents | BRISTOL-MYERS SQUIBB COMPANY | 2002-07-25 | — | — | US | disclosed |
| WO-2002026228-A1 | BENZIMIDAZOLONE ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
| US-20020016309-A1 | Imidazopyridine and imidazopyrimidine antiviral agents | BRISTOL-MEYERS SQUIBB COMPANY | 2002-02-07 | — | — | US | disclosed |
| WO-2001095910-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| EP-1098644-A1 | SUBSTITUTED BENZIMIDAZOLE ANTIVIRAL AGENTS | Bristol-Myers Squibb Company (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004900-A1 | SUBSTITUTED BENZIMIDAZOLE ANTIVIRAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |