Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842165 | 0.87 | TP53 (0.47) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL31613824 | 0.82 | POLB (0.40) | POLBLMNAMAPTTHRBTP53 | |
| SCHEMBL30842140 | 0.81 | POLB (0.42) | POLBLMNAMAPTTHRBTP53 | |
| SCHEMBL30842151 | 0.79 | KMT2A (0.49) | LMNAMAPTTP53SMN1; SMN2KMT2A | |
| SCHEMBL31613842 | 0.78 | OPRM1 (0.39) | POLBLMNAMAPTTHRBTP53 | |
| SCHEMBL31546212 | 0.73 | KIF18A (0.49) | — | |
| SCHEMBL31546213 | 0.73 | POLB (0.50) | POLBLMNAMAPTTHRBTP53 | |
| SCHEMBL31546226 | 0.73 | POLB (0.50) | POLBLMNAMAPTTHRBTP53 | |
| SCHEMBL31546227 | 0.72 | KIF18A (0.49) | — | |
| SCHEMBL31037921 | 0.72 | TP53 (0.36) | POLBLMNAMAPTTHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024051755-A1 | KIF18A INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR AND USE THEREOF | 长春金赛药业有限责任公司 | 2024-03-14 | — | — | WO | disclosed |