Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842135 | 0.87 | POLB (0.46) | TP53LMNAMAPTALDH1A1RAB9A | |
| SCHEMBL30842140 | 0.79 | POLB (0.42) | TP53LMNAMAPTALDH1A1RAB9A | |
| SCHEMBL31613824 | 0.77 | POLB (0.40) | TP53LMNAMAPTPOLB | |
| SCHEMBL31546227 | 0.74 | KIF18A (0.49) | — | |
| SCHEMBL31613842 | 0.74 | OPRM1 (0.39) | TP53LMNAMAPTRAB9APOLB | |
| SCHEMBL31037921 | 0.73 | TP53 (0.36) | TP53LMNAMAPTALDH1A1RAB9A | |
| SCHEMBL31546212 | 0.73 | KIF18A (0.49) | — | |
| SCHEMBL31037908 | 0.70 | POLB (0.52) | TP53LMNAMAPTALDH1A1RAB9A | |
| SCHEMBL31037926 | 0.70 | POLB (0.52) | TP53LMNAMAPTALDH1A1POLB | |
| SCHEMBL31546213 | 0.69 | POLB (0.50) | TP53LMNAMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024051755-A1 | KIF18A INHIBITOR COMPOUND, AND PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR AND USE THEREOF | 长春金赛药业有限责任公司 | 2024-03-14 | — | — | WO | disclosed |