Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587215 | 0.96 | SLC6A4 (0.63) | SLC6A4HTR1A | |
| SCHEMBL18011073 | 0.83 | SLC6A4 (0.56) | SLC6A4HTR1A | |
| SCHEMBL30320095 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL5791054 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL30468389 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL6879916 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL4351901 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL3103741 | 0.82 | SLC6A4 (0.73) | SLC6A4HTR1A | |
| SCHEMBL5234124 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A | |
| SCHEMBL8255694 | 0.82 | SLC6A4 (0.69) | SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163698-B | Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide | MERCK PATENT GMBH | 2011-05-18 | — | — | CN | claimed |
| US-7799916-B2 | Process for the preparation of 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxamide | MERCK PATENT GMBH (DE) | 2010-09-21 | — | — | US | claimed |
| EP-1874762-B1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | MERCK PATENT GMBH (DE) | 2009-01-14 | — | — | EP | claimed |
| US-20080293943-A1 | Process for the Preparation of 5-(4-[4-(5-Cyano-3-Indolyl)Butyl]-1-Piperazinyl)Benzofuran-2-Carboxamide | MERCK PATENT GMBH (DE) | 2008-11-27 | — | — | US | claimed |
| CN-101163698-A | Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide | MERCK PATENT GMBH (DE) | 2008-04-16 | — | — | CN | claimed |
| EP-1874762-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | Merck Patent GmbH (DE) | 2008-01-09 | — | — | EP | claimed |
| WO-2006114202-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | MERCK PATENT GMBH (DE) | 2006-11-02 | — | — | WO | claimed |
| CN-108456198-B | Preparation method of vilazodone or hydrochloride thereof | 江苏豪森药业集团有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-107501159-B | Synthesis method of vilazodone intermediate 3- (4-chlorobutyl) -5-cyanoindole | 连云港恒运药业有限公司 | 2020-11-24 | — | — | CN | disclosed |
| CN-109627237-A | A kind of preparation method of vilazodone hydrochloride | 北京济美堂医药研究有限公司 | 2019-04-16 | — | — | CN | disclosed |
| US-20190002444-A1 | CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-01-03 | — | — | US | disclosed |
| US-10011590-B2 | Crystalline forms of vilazodone hydrochloride and vilazodone free base | DR. REDDY'S LABORATORIES LIMITED (IN) | 2018-07-03 | — | — | US | disclosed |
| US-20180002305-A1 | PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES | SYMED LABS LIMITED (IN) | 2018-01-04 | — | — | US | disclosed |
| US-20080293943-A1 | Process for the Preparation of 5-(4-[4-(5-Cyano-3-Indolyl)Butyl]-1-Piperazinyl)Benzofuran-2-Carboxamide | MERCK PATENT GMBH (DE) | 2008-11-27 | — | — | US | disclosed |
| CN-101163698-A | Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide | MERCK PATENT GMBH (DE) | 2008-04-16 | — | — | CN | disclosed |
| CN-101163698-A | Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide | MERCK PATENT GMBH (DE) | 2008-04-16 | — | — | CN | disclosed |
| EP-1874762-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | Merck Patent GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| EP-1874762-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | Merck Patent GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114202-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | MERCK PATENT GMBH (DE) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006114202-A1 | METHOD FOR THE PRODUCTION OF 5-(4-[4-(5-CYANO-3-INDOLYL)-BUTYL]-1-PIPERAZINYL)-BENZOFURAN-2-CARBOXAMIDE | MERCK PATENT GMBH (DE) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002305-A1 | PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES | HTR3C, VIL1, HTR4 | SLC6A4 61/4885HTR1A 21/4885 |
| US-10011590-B2 | Crystalline forms of vilazodone hydrochloride and vilazodone free base | VIL1, VMA21, PYGL | SLC6A4 39/4885HTR1A 936/4885 |
| US-20080293943-A1 | Process for the Preparation of 5-(4-[4-(5-Cyano-3-Indolyl)Butyl]-1-Piperazinyl)Benzofuran-2-Carboxamide | IDO1, BRPF3, BRPF1 | SLC6A4 442/4885HTR1A 336/4885 |
| US-20190002444-A1 | CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE | VIL1, VMA21, PYGL | SLC6A4 39/4885HTR1A 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.