Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21773000 | 1.00 | TRPM8 (0.42) | TRPM8CNR2MMP1MMP9ACLY | |
| SCHEMBL31018047 | 0.87 | TP53 (0.39) | TRPM8ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL21783443 | 0.87 | TP53 (0.39) | TRPM8ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL31566612 | 0.78 | CNR2 (0.34) | TRPM8CNR2MMP1MMP9ACLY | |
| SCHEMBL31566999 | 0.78 | ACLY (0.41) | TRPM8CNR2MMP1MMP9ACLY | |
| SCHEMBL31567096 | 0.78 | TAS2R14 (0.41) | CNR2ACLYTAS2R14PGRCNR1 | |
| SCHEMBL31566915 | 0.78 | HDAC8 (0.39) | TRPM8CNR2MMP1MMP9ACLY | |
| SCHEMBL31018013 | 0.77 | ALDH1A1 (0.40) | CNR2MMP1MMP9TAS2R14PGR | |
| SCHEMBL31566904 | 0.77 | MMP9 (0.46) | TRPM8CNR2MMP1MMP9TAS2R14 | |
| SCHEMBL21772960 | 0.77 | SCN8A (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025096637-A1 | SUBSTITUTED ARYL SULFONAMIDES FOR USE AS SODIUM CHANNEL INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2025-05-08 | — | — | WO | disclosed |
| CN-112638898-B | Heteroaryl substituted sulfonamide compounds and their use as sodium channel inhibitors | 泽农医药公司 | 2024-04-09 | — | — | CN | disclosed |