Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033243 | 0.89 | RIPK1 (0.44) | SCDRIPK1SIGMAR1SLC18A3NPC1 | |
| SCHEMBL21033480 | 0.81 | RIPK1 (0.46) | RIPK1KDM4ESLC18A3NPC1RAB9A | |
| SCHEMBL30845782 | 0.80 | ADRA1A (0.51) | SCDRIPK1KDM4ENPC1RAB9A | |
| SCHEMBL30845765 | 0.76 | GRM2 (0.35) | RIPK1KDM4ENAMPTHSD17B10ALDH1A1 | |
| SCHEMBL30845763 | 0.71 | ALDH1A1 (0.39) | RIPK1KDM4ENPC1RAB9ANAMPT | |
| SCHEMBL21001668 | 0.71 | PRMT5 (0.52) | — | |
| SCHEMBL3664098 | 0.69 | ADRA1A (0.54) | SCDRIPK1NPC1RAB9AHCAR2 | |
| SCHEMBL12115086 | 0.67 | DHFR (0.47) | SCDDHFRSCD5 | |
| SCHEMBL4090031 | 0.66 | HDAC1 (0.50) | KDM4ENPC1RAB9ANAMPTGAA | |
| SCHEMBL5490962 | 0.66 | KCNH2 (0.56) | SCDSIGMAR1SLC18A3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |