Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 6/20 | 0.58 |
| ▸ | CLK2 | P49760 | 6/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.58 |
| ▸ | CLK3 | P49761 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 8/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.55 |
| ▸ | PIM1 | P11309 | 6/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27154225 | 1.00 | CLK1 (0.58) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL29354919 | 0.82 | ROCK2 (0.58) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL7716146 | 0.82 | ROCK2 (0.58) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL3400660 | 0.78 | AHR (0.49) | DYRK1ADYRK1BJAK2CDK2DYRK3 | |
| SCHEMBL29627852 | 0.78 | TGFBR1 (0.40) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL15344157 | 0.76 | GSK3B (0.57) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL3799521 | 0.75 | CLK1 (0.61) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30805622 | 0.75 | GSK3B (0.63) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL5014101 | 0.74 | CLK1 (0.64) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16740690 | 0.74 | NOS1 (0.72) | CLK1CLK2DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |