Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 7/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22345791 | 1.00 | ROCK2 (0.36) | ROCK2TRPV3KEAP1NFE2L2CYP1A2 | |
| SCHEMBL22345793 | 1.00 | ROCK2 (0.36) | ROCK2TRPV3KEAP1NFE2L2CYP1A2 | |
| SCHEMBL22345797 | 0.79 | TRPV3 (0.42) | ROCK2TRPV3CD274PDCD1PDCD1LG2 | |
| SCHEMBL20268380 | 0.79 | TRPV3 (0.42) | ROCK2TRPV3CD274PDCD1PDCD1LG2 | |
| SCHEMBL20268384 | 0.79 | TRPV3 (0.42) | ROCK2TRPV3CD274PDCD1PDCD1LG2 | |
| SCHEMBL30850026 | 0.79 | TRPV3 (0.42) | ROCK2TRPV3CD274PDCD1PDCD1LG2 | |
| SCHEMBL29442719 | 0.79 | TRPV3 (0.42) | ROCK2TRPV3CD274PDCD1PDCD1LG2 | |
| SCHEMBL20268528 | 0.69 | ROCK2 (0.41) | ROCK2TRPV3CD274ALDH1A1LMNA | |
| SCHEMBL20268529 | 0.69 | ROCK2 (0.41) | ROCK2TRPV3CD274ALDH1A1LMNA | |
| SCHEMBL9095902 | 0.68 | OPRK1 (0.39) | ROCK2CYP1A2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206566-A | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-113474349-B | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-03-01 | — | — | CN | disclosed |