Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL30862136

N=C(N)NN.N=C(N)NN.O=C(O)CCC(=O)C(=O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 5/20 0.61
MAPK1 P28482 1/20 0.61
SLC13A3 Q8WWT9 1/20 0.61
OR51E2 Q9H255 1/20 0.61
KDM4E B2RXH2 4/20 0.48
KDM5C P41229 4/20 0.48
PHF8 Q9UPP1 4/20 0.48
KDM2A Q9Y2K7 4/20 0.48
LMNA P02545 5/20 0.39
ALKBH5 Q6P6C2 1/20 0.39
SUCNR1 Q9BXA5 1/20 0.39
CYP1A2 P05177 3/20 0.38
TSHR P16473 2/20 0.38
NFKB1 P19838 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
THPO P40225 1/20 0.38
SLC15A2 Q16348 1/20 0.37
KDM6B O15054 2/20 0.34
GABRR1 P24046 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL28239345 0.89 KDM4E (0.59) EGLN1MAPK1SLC13A3OR51E2KDM4E
Succinic Acid SCHEMBL30862138 0.89 KDM4E (0.59) EGLN1MAPK1SLC13A3OR51E2KDM4E
Alpha-Ketoglutaric Acid SCHEMBL12274451 0.82 EGLN1 (0.54) EGLN1MAPK1SLC13A3OR51E2KDM4E
Glutarate SCHEMBL30862146 0.79 SLC22A6 (0.55) KDM4EKDM5CPHF8KDM2ALMNA
Adipic Acid SCHEMBL30862135 0.79 LMNA (0.55) KDM4EKDM5CPHF8KDM2ALMNA
Pimagedine SCHEMBL27971135 0.79 CTSD (0.45) EGLN1MAPK1SLC13A3OR51E2KDM4E
Levulinic Acid SCHEMBL27582435 0.78 LMNA (0.61) EGLN1KDM4EKDM5CPHF8KDM2A
Alpha-Ketoglutaric Acid SCHEMBL29162802 0.78 EGLN1 (0.88) EGLN1MAPK1SLC13A3OR51E2KDM4E
Alpha-Ketoglutaric Acid SCHEMBL3776640 0.78 EGLN1 (1.00) EGLN1MAPK1SLC13A3OR51E2KDM4E
Alpha-Ketoglutaric Acid SCHEMBL932116 0.78 EGLN1 (1.00) EGLN1MAPK1SLC13A3OR51E2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117836271-A Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts 西奈克制药有限公司 2024-04-05 CN claimed
CN-117836271-A Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts 西奈克制药有限公司 2024-04-05 CN disclosed