Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL4259785 | 0.86 | KDM4E (0.46) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL4821332 | 0.86 | KDM4E (0.46) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL30862143 | 0.84 | LMNA (0.43) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL439903 | 0.83 | KDM4E (0.48) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Guanidine SCHEMBL8638683 | 0.83 | BLM (0.48) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL728583 | 0.83 | KDM4E (0.48) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL9702626 | 0.80 | KDM4E (0.46) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL9797617 | 0.80 | TSHR (0.50) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Pimagedine SCHEMBL28939705 | 0.80 | KDM4E (0.46) | CYP2C19BLMKDM4ECYP2D6NPSR1 | |
| Thiourea SCHEMBL8576993 | 0.78 | BLM (0.43) | CYP2C19BLMKDM4ECYP2D6NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117836271-A | Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts | 西奈克制药有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117836271-A | Salts of phenylpyrrolaminoguanidine and polymorphs of phenylpyrrolaminoguanidine onium salts | 西奈克制药有限公司 | 2024-04-05 | — | — | CN | disclosed |